Molecular Weight: 76.09. When used in a lotion or ointment, propylene glycol increases the skin’s ability to absorb whatever it’s applied to it, which could help medications work better. 200-338-0 CAS no. Food makers value it for its ability to keep a substance moist, maintain texture, and mix with almost anything (oil, alcohol, and water). [38][41] The GRAS designation is specific to its use in food, and does not apply to other uses. matches found for [57] However, no confirmed lethality from propylene glycol was reported. This concentration has been linked to use of water-based paints and water-based system cleansers. This conversion is the basis of a potential biotechnological route to the commodity chemical 1,2-propanediol. Synonym: 1,2-Propanediol, Propylene glycol. Its chemical formula is CH3CH(OH)CH2OH. It is miscib le in water. Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to contact with food. [26] In a 2-year study, 12 rats were provided with feed containing as much as 5% propylene glycol, and showed no apparent ill effects. Site Use Terms Reproduction of any materials from the site is strictly forbidden without permission. Propylene glycol methyl ether acetate, 2 [26] The safety of electronic cigarettes—which utilize PG-based preparations of nicotine or THC and other cannabinoids—is the subject of much controversy. [67] 87% of the reactions were classified as weak and 9% as strong. Propylene glycol is available as antifreeze, but one must read the label very carefully, as most antifreeze products contain ethylene glycol. [39], The potential for long-term oral toxicity is also low. 1,2-Propanediol diacetate, [9][10] Vaporizers used for delivery of pharmaceuticals or personal-care products often include propylene glycol among the ingredients. It is a clear, colorelss, viscous liquid, slightly bitter-tasting. Page: 4/6. We have compiled a list of Propylene Glycol suppliers in the USA.Including bulk propylene glycol … [47], According to a 2010 study, the concentrations of PGEs (counted as the sum of propylene glycol and glycol ethers) in indoor air, particularly bedroom air, has been linked to increased risk of developing numerous respiratory and immune disorders in children, including asthma, hay fever, eczema, and allergies, with increased risk ranging from 50% to 180%. Sorry we cannot compare more than 4 products at a time. Containing two alcohol groups, it is classed as a diol. This page was last edited on 26 December 2020, at 00:41. Dipropylene glycol monomethyl ether, Empirical Formula (Hill Notation): C16H24O3, 9 Product Results, Empirical Formula (Hill Notation): C27H52O4, Empirical Formula (Hill Notation): C15H30O3, Synonym: The positive reaction rates were 0%, 0.26%, and 1.86% for 5%, 10%, and 20% propylene glycol respectively, increasing with each concentration increase. ", Ullmann's Encyclopedia of Industrial Chemistry, "1,2-propanediol: chemical product info at CHEMINDUSTRY.RU", "Quackmail: Why You Shouldn't Fall For The Internet's Newest Fool, The Food Babe", "Over the counter (OTC) artificial tear drops for dry eye syndrome", "Properties of Some Particular Solutions", "Windborne in Puget Sound: Why does a holding plate work? [61] Investigators believe that the incidence of allergic contact dermatitis to propylene glycol may be greater than 2% in patients with eczema or fungal infections, which are very common in countries with lesser sun exposure and lower-than-normal vitamin D balances. /LABORATORY ANIMALS: Acute Exposure/ Propylene glycol was relatively harmless (LD50 = 21 g/kg) in acute oral toxicity studies involving rats. PGMEA, Propylene glycol (often abbreviated 'PG') has many applications. Therefore, propylene glycol is considered as not persistent in the environment. It is miscible with a broad range of solvents, including water, acetone, and chloroform. Product Results, |  Match Criteria: Product Name, Property, Description, Synonym: Propylene glycol skin sensitization occurred in patients sensitive to a number of other concomitant positive allergens, most common of which were: Myroxylon pereirae resin, benzalkonium chloride, carba mix, potassium dichromate, neomycin sulfate; for positive propylene glycol reactions, the overall median of 5 and mean of 5.6 concomitant positive allergens was reported. [53] Ruddick (1972) also summarized intramuscular LD50 data for rat as 13-20 mL/kg BW, and 6 mL/kg BW for the rabbit. Propylene glycol is an approved food additive for dog and sugar glider food under the category of animal feed and is generally recognized as safe for dogs,[58] with an LD50 of 9 mL/kg. female mice that received propylene glycol in drinking water at doses up to 10,100 mg/kg bw/day. Propylene glycol or 1,2-dihydroxypropane or 1,2-propanediol, is a clear, colourless, viscous, practically odourless liquid with a density of 1.038 g/cm³ at 20°C and a molecular weight of 76.095. Although both propylene glycol and ethylene glycol have a large number of applications across a variety of industries and uses including cosmetics and preservatives (propylene glycol) and within the manufacture of resins, inks and polyethylene terephthalate (ethylene glycol) both have a common use within antifreeze and coolant mixes. Some common applications see PG used: When used in average quantities, propylene glycol has no measurable effect on development and/or reproduction on animals and probably does not adversely affect human development or reproduction. Estimated levels of exposure to propylene glycol and glycerine are close enough to [workplace limits] to warrant concern. Empirical Formula (Hill Notation): C10H12O2. So when producing in the industry, a racemic mixture is resulting. [37] It would be nearly impossible to reach toxic levels by consuming foods or supplements, which contain at most 1 g/kg of PG, except for alcoholic beverages in the US which are allowed 5 percent = 50g/kg. "Subchapter B - Food for Human Consumption. [11] Propylene glycol is used as a solvent in many pharmaceuticals, including oral, injectable, and topical formulations. [46] Recently, propylene glycol (commonly alongside glycerol) has been included as a carrier for nicotine and other additives in e-cigarette liquids, the use of which presents a novel form of exposure. According to a 2018 source, 2.16 M tonnes are produced annually. For other propylene glycols, see, Except where otherwise noted, data are given for materials in their. Exposures to propylene glycol having no adverse effects on the mother should have no effect on the fetus. Estimates on the prevalence of propylene glycol allergy range from 0.8% (10% propylene glycol in aqueous solution) to 3.5% (30% propylene glycol in aqueous solution). Birth defects are unlikely. Propylene glycol is expected to degrade rapidly in water from biological processes, but is not expected to be significantly influenced by hydrolysis, oxidation, volatilization, bioconcentration, or adsorption to sediment. Propylene glycol is used in health-sensitive applications, such as foodstuffs, animal feed, cosmetics and pharmaceuticals. Propylene glycol is a synthetic liquid substance that absorbs water. Selected toxicity information from HSDB. Compare Products: Select up to 4 products. [48][49][50], Propylene glycol has not caused sensitization or carcinogenicity in laboratory animal studies, nor has it demonstrated genotoxic potential.[51][52]. Propylene glycol is a compound which is GRAS (generally recognized as safe) by the US FDA (Food and Drug Administration) under 21 CFR x184.1666, and is also approved by the FDA for certain uses as an indirect food additive. It is a colorless, odorless, slightly syrupy liquid that is a bit thicker than water. Segít megőrizni a krém állagát (hogy a krém ne olvadjon meg nagy melegben, illetve ne fagyjon meg nagy hidegben) valamint segíti a többi összetevő beszívódását. [45] Due to the lack of chronic inhalation data, it is recommended that propylene glycol not be used in inhalation applications such as theatrical productions, or antifreeze solutions for emergency eye wash stations. It is used as aircraft de-icing fluid. Its chemical formula is CH3CH(OH)CH2OH. 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